Great Expectations – at the Royal Exchange Theatre

Posted on: August 3rd, 2023 by mlpEditor

Come along to the Theatre Group’s visit to ‘Great Expectations’ at the Royal Exchange Theatre.

From the Royal Exchange’s website:

This adaptation of a classic by Tanika Gupta is just pure genius. You’ll get to see the familiar Dickens framework, but it comes with a twist.

All my life they looked down on me, always cursing and abusing. But you, you will be different!

Bengal, 1903. Rumours that the British Empire plans to partition Bengal spread and uncertainty is never far away. For one Indian boy destiny is found on the banks of the River Padma before the Goddess Lakshmi. Here a promise is made. Born out of terror or kindness the choice Pipli makes that night will shape his life forever.

Pooja Ghai directs Tanika Gupta’s adaptation of Charles Dickens’ Great Expectations. Pipli moves from his home in Rajshahi to the bustling streets of Calcutta. With an open heart he navigates unforgiving darkness and unsettling friendships in his search for a better future. For Pipli, dharma – the right way of living, is never far away.

 

Lit & Phil members and friends are invited to book their seats directly with the theatre for the 2.30 pm matinee performance on the 20th September.

There will also be a post-theatre meal at Cote Brasserie in Manchester at 5.30 pm. This will be an opportunity to share our views about the play in a relaxed atmosphere.

Please email the organiser, Joanna Lavelle, via the button above if you would like further information or if you would like to join us.

 

Good to know: There will be an online pre-event discussion led by Dr Manju Bhavnani before the play on Tuesday 12th September at 6.30 pm via BlueJeans and an online post-event discussion on Tuesday 25th September at 6.30pm. Email the organiser via the button above for signing in details.

If you can’t go to the theatre on September 20th, you can still join in the pre-event discussion on September 12th and/or the post event discussion on September 25th.

Engineering enzymes to reduce plastic waste

Posted on: June 27th, 2023 by mlpEditor

Plastic waste is a global pollution crisis. Finding effective solutions to tackle PET plastic pollution is crucial for preserving our environment and creating a more sustainable future.

PET plastic, short for polyethylene terephthalate, is a commonly used material in bottles, containers and packaging. Unfortunately, PET plastic waste has become a significant environmental problem. When not properly recycled, PET can persist in the environment for many years, contributing to pollution in our oceans and ecosystems.

Current recycling methods for PET plastic face several challenges. The processes can be energy-intensive and costly. And the quality of recycled PET may not always be on par with virgin plastic, limiting its usability.

In 2016 scientists found an enzyme, a special type of protein, called IsPETase that can break down PET into its original building blocks. This discovery generated a lot of interest in using biological methods to recycle plastics.

But enzymes such as IsPETase are not immediately suitable to be used on a large scale, as they are not robust or efficient enough for industrial use. Whilst enzymes can be engineered to meet these industrial demands, the process is very challenging when working with plastic degrading enzymes.

In this online talk, Dr Elizabeth Bell will describe the development of a high-throughput platform for engineering plastic degrading enzymes using a process called directed evolution. Directed evolution is a mimic of natural evolution but done on a laboratory scale. It focuses on tailoring the specific properties of an enzyme to meet our requirements.

Elizabeth and her team used this platform to create a new variant of IsPETase that can withstand high temperatures and is more effective at breaking down PET. The engineered enzyme can also selectively degrade the PET component of a multi-material plastic that is commonly used for food packaging.

This study demonstrates that laboratory evolution can be used as a powerful tool to engineer enzymes to effectively break down plastics. With further research and development, these engineered enzymes could play a crucial role in reducing plastic waste and promoting a more sustainable future.

Kindness & Integrity – Leadership in a troubled world

Posted on: May 23rd, 2023 by mlpEditor

It is said people get the leaders they deserve. If this is true, can we all change so that leaders realise that leading with kindness, integrity, compassion and mutual respect is the way forward for maintaining a stable and peaceful world order?

In a special collaboration with MACFEST, the Muslim Arts and Culture Festival, the Manchester Lit & Phil are delighted and honoured to be hosting an ‘in conversation’ event with the eminent scholar, diplomat, author, poet, playwright, and polymath, Professor Akbar Ahmed.

Following a distinguished career in academia and public service, Akbar has devoted himself to the healing of the many harmful divisions between peoples and communities of different religions throughout the world, as these continue to pose serious threats to world peace.

Led by our current President, Ian Cameron, the conversation will be both an examination and a celebration of Professor Ahmed’s highly commendable multi-faceted life’s work.

In a world currently dominated by populist leaders and outright dictators, are Professor Ahmed’s noble efforts in driving towards such a change likely to succeed?

The panel will also be joined by special guest Professor Karin Vogt – an author and academic-teacher trainer at Heidelberg University, Germany. Professor Vogt is very interested in promoting diversity and intercultural understanding and we’re pleased to have the opportunity to hear her contribution to the discussion.

No Pay? No Way! – Theatre Group discussion

Posted on: May 10th, 2023 by mlpEditor

Find out more about the Royal Exchange’s production of ‘No Pay? No Way!’

This Lit & Phil member-led discussion last about 45 minutes and will include opportunities for questions and discussion among the participants.

All are welcome, whether or not you can attend the production at the Royal Exchange.

Good to know: the meeting will be online using Blue Jeans, allowing all users to be seen and to join the discussion.

Revolutionising cancer screening

Posted on: April 12th, 2023 by mlpMemberAdmin

Are we a step closer to finding a cure for cancer?

Whilst we can often successfully treat those that are diagnosed at an early stage, depending on the type of cancer, even the most effective treatments are often not effective when cancer is diagnosed at an advanced stage. For these reasons, great efforts are made to diagnose cancers as early as possible.

There is only so much that can be done to make the public and clinicians aware of the signs and symptoms. To make real progress, we need better tests and to use them in screening programs targeting seemingly healthy people.

Up until now, screening tests have been designed to look for one specific type of cancer at a time. And a significant problem is posed by the unreliability of these tests. For every early detection of cancer, several others receive a false-positive. If we were to have 20 different screening programs (one for each type of cancer), most people would receive a false-positive result once every few years. These false-positive tests cause anxiety, can lead to invasive further testing and are expensive to the NHS.

But there is hope on the horizon. Recent technological advances allow for the detection of tiny fragments of genetic material present in the blood. This, for the first time, offers the possibility of having a single blood test for many different types of cancer. One such test can detect 50 different types of cancer, with varying success, and it only very rarely gives a false positive result. If this test can find cancer early enough, it could revolutionize the way we approach cancer control.

Join us as we host Professor Peter Sasieni to learn more about this ground-breaking development in cancer research.

Demystifying Antarctica: What we’ve learned and what comes next

Posted on: March 14th, 2023 by mlpMemberAdmin

Since its discovery in 1840, polar scientists have gone to great lengths to explore Antarctica’s depths. An ice-covered continent the size of the United States and Mexico combined, it has been the site and subject of revelatory scientific studies and awe-inspiring adventures. In its vastness and mysteriousness, it has captured imaginations and has been the source of inspiration for centuries.

The significance of Antarctica’s role in the maintenance of ideal life conditions across the entire planet has since been established. Its ice, ocean and ecosystem play a vital role in the regulation of the global climate. Although many questions remain about its past and its present, particular attention has been turned to the future of its ice sheet. Concerns about its diminishing size have been at the heart of the polarising climate change debate.

Professor Helen Fricker will speak of the physical processes which determine the state of the ice, the transformational impact of satellite observation on her studies as well as the effects that the atmosphere and the oceans have on the ice. We will ask her how the future of Antarctic ice will affect sea levels globally.

As getting to grips with Antarctica involves a range of specialisms and extensive international collaboration, Helen will go beyond her background in geophysics to provide us with a comprehensive understanding of the continent. As one of an increasing number of women polar scientists, we look forward to hearing from someone who has first-hand experience of seeing the effects of climate change.

This online event has been organised in collaboration with the Institute of Physics.

Find out more about the IoP here: https://www.iop.org

Cat on a Hot Tin Roof – Theatre Group discussion

Posted on: January 30th, 2023 by mlpEditor

Find out more about Tennessee Williams as a playwright, the context in which he was writing and the themes he tackled.

This Lit & Phil member-led discussion will consist of an informal introduction to Tennessee Williams’ play, Cat on a Hot Tin Roof, prior to our visit to see the production at the Royal Exchange Theatre.

A short presentation will be given by Tony Jackson, with additional input from Joanna Lavelle. As well as providing some background to the play and Williams, especially the battles he had with stage and film directors over this particular play, some questions and talking points will be suggested to consider when attending the performance.

The session will be about 45 minutes long and will include opportunities for questions and discussion among the participants.

All are welcome, whether or not you can attend the production at the Royal Exchange.

Good to know: the meeting will be online using Blue Jeans, allowing all users to be seen and to join the discussion. There will also be a post-production on-line discussion on April 25th at 6.30pm via Blue Jeans.

Food and climate change

Posted on: January 24th, 2023 by mlpEditor

About a quarter of all greenhouse gas emissions come from food; global emissions average 6 kg CO2e per person per day, ranging from less than 2 kg/day in Africa to 13 kg/day in the US.

Controlling emissions to limit temperature rise cannot be achieved without a very large reduction in food related emissions. This means changes in diets and food production. How might this be done? And what can we do as individuals?

These, and other questions you want to raise, will be considered during this online session.

Our main speakers are Peter Ball (Professor of Operations Management at the University of York) and Beckie Lait (also at the University of York carrying out PhD research with fixourfood.org). They will respectively explore systems thinking behind UK farming practice (in particular, urban farming) and the carbon footprints of our food choices.

Following their introductions there will be ample time for your questions, suggestions and comments.

Good to know: the meeting will be online using the BlueJeans meetings app, allowing all users to be seen and to join the discussion.

Further reading: Professor Sarah Bridle – who gave an online talk to the Lit & Phil – sets out the problems in her book “Food and Climate Change” – a highly recommended source (and available as a free e-book).

Free speech: its past, present and future

Posted on: January 5th, 2023 by mlpEditor

How can we better understand and conceptualise both the benefits and challenges of free speech?

It has been said that ‘free speech is the bulwark of liberty; without it, no free and democratic society has ever been established or thrived’. But how can we protect it whilst addressing legitimate concerns surrounding misinformation and hate speech?

In this online ‘in conversation’ event, Danish lawyer and human-rights advocate, Jacob Mchangama, will explore the past, present and future of free speech with Paul Cartledge, Professor of Greek Culture at Cambridge University.

Drawing on Professor Cartledge’s expertise in ancient history and democracy, the conversation will begin with a discussion of where and how the very idea of free speech originated.

Jacob and Paul will explore the ancient concepts of “Isegoria” (equality of all in freedom of speech) and “Parrhesia” (speaking candidly). And the difference, indeed conflict, between “egalitarian” free speech in Athens vs “elitist” free speech in the Roman Republic. Using illustrative examples – including the trial of Socrates and the Peterloo Massacre – they will explain how this conflict between egalitarian and elitist free speech has been a major fault line through ancient, medieval, and modern history.

What lessons can the difficulties of invoking the ideal of free speech in the ancient world tell us about the difficulties of operationalizing this ideal in today’s digital world? And how can we create a resilient global culture of free speech that benefits everyone?

*The Dalton Lecture* – What is life?

Posted on: December 7th, 2022 by mlpEditor

Multi-award-winning scientist Sir Paul Nurse considers the most fundamental question in biology, “What is Life?”

In a highly anticipated talk, Sir Paul will seek to answer this profound question by first exploring five great ideas in biology:

The cell – the fundamental unit of all living things

The gene – how do cells store, preserve and pass on information?

Evolution by natural selection – how is genetic information accurately transmitted to subsequent generations, whilst at the same time introducing sufficient variability for natural selection to operate and for new species to arise?

Life as chemistry – how do cells host myriad simultaneous chemical reactions in a minute space? What is the central role of carbon polymer chemistry?

Life as information – how do cells and organisms regulate and coordinate their internal environment? And how do they respond to stimuli and conditions in their external environment?

From consideration of these five fundamental concepts, Sir Paul will relate a number of principles which set a direction of travel towards a definition of life – something that requires more than just a description of what living things do.

His book “What is Life” has been published in 22 countries.